Nuclear morphometry as a biomarker for bronchial intraepithelial neoplasia: Correlation with genetic damage and cancer development

Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia

Pancreatic cancer is one of the most aggressive cancers and has an extremely poor prognosis. Despite recent progress in both basic and clinical research, most pancreatic cancers are detected at an incurable stage owing to the absence of disease-specific symptoms. Thus, developing novel approaches for detecting pancreatic cancer at an early stage is imperative. Our in silico and immunohistochemi...

Evaluation of P16INK4A as a Biomarker in Cervical Intraepithelial Neoplasia

Introduction: Cervical screening would benefit from a test based on a disease-specific biomarker that identifies high grade lesions, which could also indicate the presence of early precancerous lesions that have a high risk of progression to cancer. One such potential biomarker is p16INK4A. Objective of the study was to study the biomarker p16INK4A expression by immunostaining in cervical intra...

Biomarker for Occult Cancer of Human Lungs and Bronchial Heterogeneous Nuclear Ribonucleoprotein B1 as Early Cancer

Heterogeneous nuclear ribonucleoprotein (hnRNP) B1 is a RNAbinding protein of Mr 37,000. We previously reported that hnRNP B1 was specifically overexpressed in the nuclei of human lung cancer cells, particularly in squamous cell carcinoma (E. Sueoka et al., Cancer Res., 59: 1404 –1407, 1999). We extended this study to determine whether hnRNP B1 was overexpressed in roentgenographically occult c...

AKNA as Genetic Risk Factor for Cervical Intraepithelial Neoplasia and Cervical Cancer

Zic1 Promoter Hypermethylation in Plasma DNA Is a Potential Biomarker for Gastric Cancer and Intraepithelial Neoplasia

Gastric cancer (GC) remains one of the most common digestive cancers worldwide; however, most patients present at an advanced stage at initial diagnosis. Zic1 is a novel candidate tumor suppressor gene that is epigenetically silenced in GC. In this study, we investigated Zic1 promoter methylation in plasma DNA as a novel molecular marker for the early diagnosis and monitoring of GC. Methylation...